Fresh water tends to increasingly comprise a scarcity today both in arid or demographically boosted regions of the world such as large and smaller cities. On this basis, research is directed towards minimization of fresh water supply into a Waste Water Network Topology (WWNT) and maximizing water re-use. This might be composed of a cluster of agents which have certain demands for fresh water as well as waste water dependent on their daily uses and living profiles. This work is divided into two parts. In the first part, different waste water flows within a reference building unit i.e. a typical household of four (4) occupants is simulated. This type of building represents a major part of the total building stock in Luxembourg. In its first part the present study attempts to examine the optimized fresh and waste water flow pathways between water using units of the building. Between water flows two domestic treatment units are adopted. The simulation of above mentioned system is attempted by adopting different algorithm methods such as the Sequential Quadratic Programming (SQP), the interior point and meta-heuristic optimization algorithms such as the Genetic Algorithms (GA’s).Suitable computational platform tools such as MATLAB and GAMS are incorporated. A comparison study on the most efficient approach is then realized on the single household unit by developing four (4) different mathematical model formulation versions. The second part of this study comprises simulation and development of the Waste Water Network Grid (WWNG) in the upscale level, such as the neighborhood level within or outside the urban context. This model encompasses all possible land uses and different kinds of buildings of different use envelopes thus demands. This range of units includes mainly building stock, agricultural and infrastructure of the tertiary sector. Integration of above mentioned model to the existing WWNG will enhance attempts to more closely reach the optimum points. The use of appropriate mathematical programming methods ...