PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population
Background: Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate PEAR1 rs12041331 as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in PEAR1 predicts cardiovascular outcome in a white population. Methods: In 1938 participants enrolled in the Flemish Study on Environment, Genes and Health Outcomes (51.3% women; mean age 43.6yea... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2017 |
Verlag/Hrsg.: |
BioMed Central
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Schlagwörter: | Cardiovascular risk / Clinical genetic / PEAR1 / Population science / Replication research / Genetic / Genetics (clinical) / Settore MED/03 - Genetica Medica / Settore BIO/18 - Genetica |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26705571 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/2434/504067 |