Inactive Matrix Gla Protein Is Causally Related to Adverse Health Outcomes ; A Mendelian Randomization Study in a Flemish Population
Matrix Gla-protein is a vitamin K–dependent protein that strongly inhibits arterial calcification. Vitamin K deficiency leads to production of inactive nonphosphorylated and uncarboxylated matrix Gla protein (dp–ucMGP). The risk associated with dp–ucMGP in the population is unknown. In a Flemish population study, we measured circulating dp–ucMGP at baseline (1996–2011), genotyped MGP , recorded adverse health outcomes until December 31, 2012, and assessed the multivariable-adjusted associations of adverse health outcomes with dp–ucMGP. We applied a Mendelian randomization analysis using MGP ge... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2015 |
Reihe/Periodikum: | Hypertension ; volume 65, issue 2, page 463-470 ; ISSN 0194-911X 1524-4563 |
Verlag/Hrsg.: |
Ovid Technologies (Wolters Kluwer Health)
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Schlagwörter: | Internal Medicine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26700357 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1161/hypertensionaha.114.04494 |