Review of: A DGGE system for comprehensive mutation screening of BRCA1 and BRCA2 : application in a Dutch cancer clinic setting

Citation of original article: van der Hout AH, et al . A DGGE system for comprehensive mutation screening of BRCA1 and BRCA2 : application in a Dutch cancer clinic setting. Human Mutat 2006; 27 (7): 654–666. Abstract of the original article: Rapid and reliable identification of deleterious changes in the breast cancer genes BRCA1 and BRCA2 has become one of the major issues in most DNA services laboratories. To rapidly detect all possible changes within the coding and splice site determining sequences of the breast cancer genes, we established a semiautomated denaturing gradient gel electropho... Mehr ...