Structure determination of extracellular fragments of amyloid proteins involved in Alzheimer's disease and Dutch‐type hereditary cerebral haemorrhage with amyloidosis

Amyloid deposition is a biochemical and histopathologic hallmark of various clinical forms of amyloidoses including Alzheimer's disease and the Dutch‐type hereditary cerebral haemorrhage with amyloidosis. The self‐aggregating peptides responsible for these irreversible deposits have been sequenced but the mechanisms involved in the aggregation processes are not well understood. In order to gain an understanding of the possible structures prior to self‐association, the extracellular fragment of the Alzheimer amyloid protein (βA4) responsible for the deposits (the ‘native’ fragment) and a mutant... Mehr ...