Frequency and nature of drug–drug interactions in a Dutch university hospital

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Drug–drug interactions (DDIs) may lead to often preventable adverse drug events and health damage. • In Dutch community pharmacies approximately 6% of all prescriptions generate a DDI alert. • Hospitalized patients may be especially at risk, as they are more severely ill and multiple medications may be prescribed simultaneously; however, only limited data are available on the frequency and nature of DDIs during hospitalization. WHAT THIS STUDY ADDS • In a Dutch university hospital 10% of all prescriptions generated a DDI alert; overall 25% of patients... Mehr ...