Effects of FGF‐2 Overexpression in the Dutch/Iowa APP Transgenic Mouse

Intracerebroventricular‐injected fibroblast growth factor (FGF)‐2 causes cerebrospinal fluid (CSF) stagnation and a normal‐pressure hydrocephalus (NPH)‐like syndrome in rats. NPH may be part of a pathophysiologic continuum culminating in Alzheimer disease (AD), at least in the context of amyloid‐β (Aβ) retention and plaque formation. We have examined transgenic mice with variable degrees of FGF‐2 and Aβ generation within the CNS and have active breeding pairs of TgFGF2xTgAPP (APP = amyloid precursor protein) to provide TgFGF2, TgAPP, and TgFGF2xTgAPP offspring. A coronal section was made throu... Mehr ...