Tofacitinib for ulcerative colitis:results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry

Background: Tofacitinib is a Janus kinase inhibitor approved for the treatment of ulcerative colitis (UC). Aim: To evaluate effectiveness, safety and use of tofacitinib in daily practice. Methods: UC patients initiating tofacitinib were prospectively enrolled in 15 hospitals in the Netherlands. Corticosteroid-free clinical remission (short clinical colitis activity index [SCCAI] ≤2), biochemical remission (faecal calprotectin level ≤250 µg/g), combined corticosteroid-free clinical and biochemical remission, predictors of remission, safety outcomes, treatment dose and effect on lipids were dete... Mehr ...

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Verfasser: Biemans, Vince B.C.
Sleutjes, Jasmijn A.M.
de Vries, Annemarie C.
Bodelier, Alexander G.L.
Dijkstra, Gerard
Oldenburg, Bas
Löwenberg, Mark
van Bodegraven, Adriaan A.
van der Meulen-de Jong, Andrea E.
de Boer, Nanne K.H.
Srivastava, Nidhi
West, Rachel L.
Römkens, Tessa E.H.
Horjus Talabur Horje, Carmen S.
Jansen, Jeroen M.
van der Woude, C. Janneke
Hoekstra, Jildou
Weersma, Rinse K.
van Schaik, Fiona D.M.
Hoentjen, Frank
Pierik, Marieke J.
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Biemans , V B C , Sleutjes , J A M , de Vries , A C , Bodelier , A G L , Dijkstra , G , Oldenburg , B , Löwenberg , M , van Bodegraven , A A , van der Meulen-de Jong , A E , de Boer , N K H , Srivastava , N , West , R L , Römkens , T E H , Horjus Talabur Horje , C S , Jansen , J M , van der Woude , C J , Hoekstra , J , Weersma , R K , van Schaik , F D M , Hoentjen , F , Pierik , M J & the Dutch Initiative on Crohn and Colitis (ICC) 2020 , ' Tofacitinib for ulcerative colitis : results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry ' , Alimentary Pharmacology and Therapeutics , vol. 51 , no. 9 , pp. 880-888 . https://doi.org/10.1111/apt.15689
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26687664
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vumc.nl/en/publications/31ecdfd7-3321-4b14-9a46-300424aa9fff