Resequencing Three Candidate Genes for Major Depressive Disorder in a Dutch Cohort
Major depressive disorder (MDD) is a psychiatric disorder, characterized by periods of low mood of more than two weeks, loss of interest in normally enjoyable activities and behavioral changes. MDD is a complex disorder and does not have a single genetic cause. In 2009 a genome wide association study (GWAS) was performed on the Dutch GAIN-MDD cohort. Many of the top signals of this GWAS mapped to a region spanning the gene PCLO, and the non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became genome wide significant after post-hoc analysis. We performed rese... Mehr ...
Verfasser: |
Verbeek, E.C.
Bevova, M.R.
Bochdanovits, Z.
Rizzu, P.
Bakker, I.M.C.
Uithuisje, T.
de Geus, E.J.C.
Smit, J.H.
Penninx, B.W.J.H.
Boomsma, D.I.
Hoogendijk, W.J.G.
Heutink, P. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2013 |
Reihe/Periodikum: |
Verbeek , E C , Bevova , M R , Bochdanovits , Z , Rizzu , P , Bakker , I M C , Uithuisje , T , de Geus , E J C , Smit , J H , Penninx , B W J H , Boomsma , D I , Hoogendijk , W J G & Heutink , P 2013 , ' Resequencing Three Candidate Genes for Major Depressive Disorder in a Dutch Cohort ' , PLoS ONE , vol. 8 , no. 11 , e79921 , pp. e79921 . https://doi.org/10.1371/journal.pone.0079921 |
Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26687107 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://research.vu.nl/en/publications/b2826429-205e-460a-ae5c-9d65c2fdfed4 |