The Dutch Orthopaedic Association has a long tradition of development of practical clinical guidelines. Here we present the recommendations from the multidisciplinary clinical guideline working group for anterior cruciate ligament injury. The following 8 clinical questions were formulated by a steering group of the Dutch Orthopaedic Association. center dot What is the role of physical examination and additional diagnostic tools? center dot Which patient-related outcome measures should be used? center dot What are the relevant parameters that influence the indication for an ACL reconstruction? center dot Which findings or complaints are predictive of a bad result of an ACL injury treatment? center dot What is the optimal timing for surgery for an ACL injury? center dot What is the outcome of different conservative treatment modalities? center dot Which kind of graft gives the best result in an ACL reconstruction? center dot What is the optimal postoperative treatment concerning rehabilitation, resumption of sports, and physiotherapy? These 8 questions were answered and recommendations were made, using the "Appraisal of Guidelines for Research and Evaluation" instrument. This instrument seeks to improve the quality and effectiveness of clinical practical guidelines by establishing a shared framework to develop, report, and assess. The steering group has also developed 7 internal indicators to aid in measuring and enhancing the quality of the treatment of patients with an ACL injury, for use in a hospital or practice.