CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL):study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial
Background: Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date, no therapy is available to improve long-term neurodevelopmental outcomes of CCHD neonates. Allopurinol, a xanthine oxidase inhibitor, prevents the formation of reactive oxygen and nitrogen species, thereby limiting cell damage during reperfusion and reoxygenation to the brain and heart. Animal and neonatal studies suggest that allopurinol reduces hypoxic-ischemic brain injury and is card... Mehr ...
Verfasser: |
Stegeman, Raymond
Nijman, Maaike
Breur, Johannes M.P.J.
Groenendaal, Floris
Haas, Felix
Derks, Jan B.
Nijman, Joppe
van Beynum, Ingrid M.
Taverne, Yannick J.H.J.
Bogers, Ad J.J.C.
Helbing, Willem A.
de Boode, Willem P.
Bos, Arend F.
Berger, Rolf M.F.
Accord, Ryan E.
Roes, Kit C.B.
de Wit, G. Ardine
Jansen, Nicolaas J.G.
Benders, Manon J.N.L. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2022 |
Reihe/Periodikum: |
Stegeman , R , Nijman , M , on behalf of the CRUCIAL trial consortium , Breur , J M P J , Groenendaal , F , Haas , F , Derks , J B , Nijman , J , van Beynum , I M , Taverne , Y J H J , Bogers , A J J C , Helbing , W A , de Boode , W P , Bos , A F , Berger , R M F , Accord , R E , Roes , K C B , de Wit , G A , Jansen , N J G & Benders , M J N L 2022 , ' CeRebrUm and CardIac Protection with ALlopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL) : study protocol of a phase III, randomized, quadruple-blinded, placebo-controlled, Dutch multicenter trial ' , Trials , vol. 23 , no. 1 , 174 . https://doi.org/10.1186/s13063-022-06098-y |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26684429 |
Datenquelle: |
BASE;
Originalkatalog |
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https://pure.eur.nl/en/publications/887d4f58-583a-42b0-ac96-cb2133fd6c9b |