Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)
The current Dutch Pharmacogenetics Working Group (DPWG) guideline, describes the gene–drug interaction between CYP2D6 and the opioids codeine, tramadol and oxycodone. CYP2D6 genotype is translated into normal metaboliser (NM), intermediate metaboliser (IM), poor metaboliser (PM) or ultra-rapid metaboliser (UM). Codeine is contraindicated in UM adults if doses >20 mg every 6 h (q6h), in children ≥12 years if doses >10 mg q6h, or with additional risk factors. In PMs, an alternative analgesic should be given which is not or to a lesser extent metabolised by CYP2D6 (not tramadol). In IMs wit... Mehr ...
Verfasser: |
Matic, Maja
Nijenhuis, Marga
Soree, Bianca
de Boer-Veger, Nienke J.
Buunk, Anne Marie
Houwink, Elisa J.F.
Mulder, Hans
Rongen, Gerard A.P.J.M.
Weide, Jan van der
Wilffert, Bob
Swen, Jesse J.
Guchelaar, Henk Jan
Deneer, Vera H.M.
van Schaik, Ron H.N. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2022 |
Reihe/Periodikum: |
Matic , M , Nijenhuis , M , Soree , B , de Boer-Veger , N J , Buunk , A M , Houwink , E J F , Mulder , H , Rongen , G A P J M , Weide , J V D , Wilffert , B , Swen , J J , Guchelaar , H J , Deneer , V H M & van Schaik , R H N 2022 , ' Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone) ' , European Journal of Human Genetics , vol. 30 , no. 10 , pp. 1105–1113 . https://doi.org/10.1038/s41431-021-00920-y |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26683800 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://pure.eur.nl/en/publications/08d928d6-5a3d-46af-b172-b5bb4ae4354d |