Vitamin E but not 17B-estradiol protect against vascular toxicity induced by B-amyloid wild type and the Dutch amyploid variant
Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called hereditary cerebral hemorrhage with amyloidosis of the Dutch type is caused by a point mutation in Aβ yielding AβGlu22→Gln. The present study addresses the effect of amyloid fibrils from both wild-type and mutated Aβ on vascular cells, as well as the putative protective role of antioxidants on amyloid angiopathy. For this purpose, we studied the cytotoxicity induced by Aβ1–4... Mehr ...
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Dokumenttyp: | Artikel |
Verlag/Hrsg.: |
Society for Neuroscience
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Schlagwörter: | Alzheimer / Malaltia d' -- Fisiologia patològica / Proteïna beta-amiloide / Estrès oxidatiu -- Fisiologia patològica / Alzheimer’s disease / CAA / HCHWA-D / Amyloid / Vitamin E / 17B-estradiol / Vitamin C / Oxidative stress / Acetylcholinesterase / Endothelial cells / Vascular smooth muscle cells |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26683688 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://hdl.handle.net/10230/16666 |