Outpatient antibiotic use in Dutch infants after 10-valent pneumococcal vaccine introduction : a time-series analysis

OBJECTIVE: This population-based cohort study assesses the impact of switching from a 7-valent pneumococcal conjugate vaccine (PCV) to a 10-valent PCV on outpatient antibiotic use in Dutch infants, and whether geographical vaccination coverage modifies this association. SETTING AND PARTICIPANTS: We extracted 2006-2013 anonymised antibiotic purchase data of 255 154 Dutch infants aged below 2 years from Achmea Health, a health insurance fund covering 28% of the national population. DESIGN AND MAIN OUTCOME MEASURE: Changes in monthly antibiotic use from 2006-2011 (PCV7) to 2011-2013 (PCV10) were... Mehr ...