Antihistamines and driving ability: Evidence from 30 years Dutch on-road driving research

Background: Since all antihistamines are capable of crossing the blood-brain barrier, they may also cause sedation which may impair daily activities such as driving a car. The purpose of this review was to examine the effects of antihistamines on driving ability. Method: A literature search revealed 18 double-blind placebo-controlled clinical trials that applied the on-road highway driving test. In this test, subjects are instructed to drive 100-km on a public highway with a steady lateral position and a constant speed (95 km/h). Primary outcome measure is the Standard Deviation of Lateral Pos... Mehr ...