Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
We obtained conclusive linkage of Alzheimer disease (AD) with a candidate region of 19.7 cM at 7q36 in an extended multiplex family, family 1270, ascertained in a population-based study of early-onset AD in the northern Netherlands. Single-nucleotide polymorphism and haplotype association analyses of a Dutch patient-control sample further supported the linkage at 7q36. In addition, we identified a shared haplotype at 7q36 between family 1270 and three of six multiplex AD-affected families from the same geographical region, which is indicative of a founder effect and defines a priority region o... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2005 |
Schlagwörter: | *Chromosomes / Human / Pair 7 / *Genetics / Population / *Linkage (Genetics) / Aged / Alzheimer Disease/*genetics / Female / Humans / Male / Middle Aged / Netherlands / Pedigree / Polymorphism / Single Nucleotide / Research Support / Non-U.S. Gov't |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26677944 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/8490 |