Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population

Background: Despite extensive research on the genetic determinants of glaucoma, the genes identified to date explain only a small proportion of cases in the general population. Methods: Genome-wide linkage and association analyses of quantitative traits related to glaucoma were performed: intraocular pressure, size and morphology of the optic disc (individual and combined by method of principal components) and thickness of the retinal nerve fibre layer (RNFL), in a large pedigree from a genetically isolated Dutch population. Results: For the size of the optic disc, the study demonstrated a sig... Mehr ...