Innovation Paradox in Vaccine Target Selection

Public health is continually threatened by re- and newly emerging infections, as well as pathogen resistance to available intervention strategies, including vaccines. This persistent threat of the unmet medical need challenges vaccine developers to anticipate future epidemiological outbreaks. Nevertheless, there are insufficient resources available to address all unmet medical needs: developing the average vaccine candidate from the symbolic ‘bench to bedside’ takes approximately 10 years requiring an investment exceeding €400 million. Furthermore, vaccine development is affected by the so-cal... Mehr ...