A decade of biologic treatment observation in juvenile idiopathic arthritis: Lessons learned from the Dutch ABC Register

Since 1999, the treatment of juvenile idiopathic arthritis (JIA) has been extended with a new category of drugs: biologic agents (also known as biologicals or biologic disease modifying anti-rheumatic drugs). Biologic agents consist of natural proteins, like antibodies and cytokines, and have been developed to target one or more steps of the immune response. Elucidation of many of the cellular and molecular mechanisms of the immune system involved in inflammatory arthritis has resulted in an increasing development of different biologic agents and, in the future, this number will expand even fu... Mehr ...