A genome-wide linkage scan in a Dutch family identifies a premature ovarian failure susceptibility locus
BACKGROUND: Premature ovarian failure (POF) is characterized by elevated gonadotrophins and amenorrhea before the age of 40 years and occurs approximately in 1% of women. POF etiology is highly heterogeneous with a wide spectrum of etiological pathogenic mechanisms including genetic causes. These mostly involve numerical, structural or monogenic defects on the X-chromosome. Mutations in a small number of autosomal genes (such as FOXL2 and NOBOX) have been identified as a cause of POF. However, in most cases, the disease underlying mechanisms are largely unknown. METHODS: We performed a genome-... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2008 |
Schlagwörter: | Familial / Genome-wide search / Linkage analysis / Premature ovarian failure / SNPs |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26677681 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/29501 |