A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy
Background: Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them. Methods: The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample from the southwestern Netherlands. Variance components linkage analyses were performed using Merlin. Regions of interest (LOD > 1.9) were fine-mapped using microarray and exome seq... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Schlagwörter: | Chromosome 11 / Chromosome 15 / Dutchman / Exome Analysis / Gene / Gene Locus / Genetic Analysis / Genetic Association / Genetic Variability / Heart Left Ventricle Hypertrophy / Human / Limit Of Detection / Linkage Analysis / Major Clinical Study / Male / Map3K11 Gene / Microarray Analysis / Netherlands / Priority Journal / Whole Exome Sequencing / Cromosoma 11 / Cromosoma 15 / Enfermedades / Cardiomegalia / Enfermedades cardiovasculares / Adult / Article / Female / Middle Aged |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26677043 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://repository.urosario.edu.co/handle/10336/20386 |