Purpose: The clinical use of event-related potentials in patients with language disor-ders is increasingly acknowledged. For this purpose, normative data should be avail-able. Within this context, healthy aging and gender effects on the electrophysiologi-cal correlates of semantic sentence comprehension were investigated.Method: One hundred and ten healthy subjects (55 men and 55 women), divided among three age groups (young, middle aged, and elderly), performed a semantic sen-tence congruity task in the visual modality during electroencephalographic recording.Results: The early visual complex was affected by increasing age as shown by smaller P2 amplitudes in the elderly compared to the young. Moreover, the N400 effect in the elderly was smaller than in the young and was delayed com-pared to latency measures in both middle-aged and young subjects. The topog-raphy of age-related amplitude changes of the N400 effect appeared to be gen-der specific. The late positive complex effect was increased at frontal electrode sites from middle age on, but this was not statistically significant. No gender effects were detected regarding the early P1, N1, and P2, or the late positive complex effect.Conclusion: Especially aging effects were found during semantic sentence comprehension, and this from the level of perceptual processing on. Normative data are now available for clinical use.