Generalizability of Dutch Prediction Models for Low Hemoglobin Deferral: A Study on External Validation and Updating in Swiss Whole Blood Donors

Background: Sex-specific prediction models for low hemoglobin (Hb) deferral have been developed in Dutch whole blood donors. In this study, we validated and updated the models in a cohort of Swiss whole blood donors. Methods: Prospectively collected data from 53,772 Swiss whole blood donors were used. The predictive performance of the Dutch models was assessed in terms of calibration (agreement between predicted probabilities and observed frequencies) and discrimination (ability to discriminate between deferred and approved donors). The models were updated by revising the strength of the indiv... Mehr ...