Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation:A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial
Objective: Sildenafil is under investigation as a potential agent to improve uteroplacental perfusion in fetal growth restriction (FGR). However, the STRIDER RCT was halted after interim analysis due to futility and higher rates of persistent pulmonary hypertension and mortality in sildenafil-exposed neonates. This hypothesis-generating study within the Dutch STRIDER trial sought to understand what happened to these neonates by studying their regional tissue oxygen saturation (rSO2) within the first 72 h after birth. Methods: Pregnant women with FGR received 25 mg placebo or sildenafil thrice... Mehr ...
Verfasser: |
Terstappen, Fieke
Richter, Anne E
Lely, A Titia
Hoebeek, Freek E
Elvan-Taşpınar, Ayten
Bos, Arend F
Ganzevoort, Wessel
Pels, Anouk
Lemmers, Petra M
Kooi, Elisabeth M W |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
Terstappen , F , Richter , A E , Lely , A T , Hoebeek , F E , Elvan-Taşpınar , A , Bos , A F , Ganzevoort , W , Pels , A , Lemmers , P M & Kooi , E M W 2020 , ' Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation : A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial ' , Frontiers in Pediatrics , vol. 8 , 595693 . https://doi.org/10.3389/fped.2020.595693 |
Schlagwörter: |
fetal growth restriction
/ Hemodynamics
/ near-infrared spectroscopy
/ regional oxygenation
/ sildenafil
/ PHARMACOKINETICS
/ PREGNANCY
/ OUTCOMES
/ FLOW |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26672079 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://hdl.handle.net/11370/e8a92a2c-da44-4c30-b83e-0f57201b962a |