Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study):a prospective non-randomised multicentre study
Background: Risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 is currently recommended to BRCA1/2 mutation carriers. This procedure decreases the elevated ovarian cancer risk by 80-96 % but it initiates premature menopause as well. The latter is associated with short-term and long-term morbidity, potentially affecting quality of life (QoL). Based on recent insights into the Fallopian tube as possible site of origin of serous ovarian carcinomas, an alternative preventive strategy has been put forward: early risk-reducing salpingectomy (RRS) and delayed oophorectomy (RRO). However,... Mehr ...
Verfasser: |
Harmsen, Marline G.
Arts-de Jong, Marieke
Hoogerbrugge, Nicoline
Maas, Angela H. E. M.
Prins, Judith B.
Bulten, Johan
Teerenstra, Steven
Adang, Eddy M. M.
Piek, Jurgen M. J.
van Doorn, Helena C.
van Beurden, Marc
Mourits, Marian J. E.
Zweemer, Ronald P.
Gaarenstroom, Katja N.
Slangen, Brigitte F. M.
Vos, M. Caroline
van Lonkhuijzen, Luc R. C. W.
Massuger, Leon F. A. G.
Hermens, Rosella P. M. G.
de Hullu, Joanne A. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2015 |
Reihe/Periodikum: |
Harmsen , M G , Arts-de Jong , M , Hoogerbrugge , N , Maas , A H E M , Prins , J B , Bulten , J , Teerenstra , S , Adang , E M M , Piek , J M J , van Doorn , H C , van Beurden , M , Mourits , M J E , Zweemer , R P , Gaarenstroom , K N , Slangen , B F M , Vos , M C , van Lonkhuijzen , L R C W , Massuger , L F A G , Hermens , R P M G & de Hullu , J A 2015 , ' Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study) : a prospective non-randomised multicentre study ' , BMC Cancer , vol. 15 , 593 . https://doi.org/10.1186/s12885-015-1597-y |
Schlagwörter: |
GRADE SEROUS CARCINOMA
/ HEREDITARY OVARIAN-CANCER
/ FEMALE SEXUAL FUNCTION
/ DISTRESS SCALE FSDS
/ FALLOPIAN-TUBE
/ INTRAEPITHELIAL CARCINOMA
/ PROPHYLACTIC SALPINGECTOMY
/ CLIMACTERIC SCALE
/ DUTCH POPULATION
/ FAMILY-HISTORY |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26671482 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://hdl.handle.net/11370/a5ccec59-269e-45a3-abab-42be3629ba99 |