The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus:Cross-Sectional and Longitudinal Analyses From the Lifelines Cohort and Biobank Study
OBJECTIVE: A strong genetic predisposition for type 2 diabetes mellitus (T2DM) may aggravate the negative effects of low socioeconomic position (SEP) in the etiology of the disorder. This study aimed to examine cross-sectional and longitudinal associations and interactions of a genetic risk score (GRS) and SEP with T2DM, and to investigate whether clinical and behavioral risk factors can explain these associations and interactions. METHODS: We used data from 13,027 genotyped participants from the Lifelines study. The GRS was based on single-nucleotide polymorphisms (SNPs) genome-wide associate... Mehr ...
Verfasser: |
van Zon, Sander K. R.
Reijneveld, Sijmen A.
van der Most, Peter Johannes
Snieder, Harold
Bultmann, Ute
Swertz, Morris |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
van Zon , S K R , Reijneveld , S A , van der Most , P J , Snieder , H , Bultmann , U & Swertz , M 2018 , ' The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus : Cross-Sectional and Longitudinal Analyses From the Lifelines Cohort and Biobank Study ' , Psychosomatic Medicine , vol. 80 , no. 3 , pp. 252-262 . https://doi.org/10.1097/PSY.0000000000000562 |
Schlagwörter: |
Journal Article
/ type 2 diabetes mellitus
/ LifeLines Cohort Study
/ genetic risk score
/ socioeconomic position
/ genetic predisposition
/ cross-sectional
/ longitudinal
/ PREVENTION
/ GENOME-WIDE ASSOCIATION
/ STYLE RISK-FACTORS
/ LIFE-STYLE
/ DUTCH ADULTS
/ DISEASE
/ OBESITY
/ MEN
/ SUSCEPTIBILITY
/ METAANALYSIS |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26671470 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://hdl.handle.net/11370/a4482dcc-4ef6-43f0-a420-88b55a54f6a5 |