Dexamethasone for the Prevention of a Pain Flare After Palliative Radiation Therapy for Painful Bone Metastases:The Multicenter Double-Blind Placebo-Controlled 3-Armed Randomized Dutch DEXA Study
Purpose: After radiation therapy for painful bone metastases, up to 44% of patients report a pain flare (PF). Our study compared 2 dose schedules of dexamethasone versus placebo to prevent PF. Methods and Materials: This double-blind, randomized, placebo-controlled trial allocated patients with painful bone metastases from solid tumors randomly to receive 8 mg dexamethasone before radiation therapy followed by 3 daily doses (group A), 8 mg dexamethasone followed by 3 doses of placebo (group B), or 4 doses of placebo (group C). Patients reported worst pain scores, study medication side effects,... Mehr ...
Verfasser: |
van der Linden, Yvette M
Westhoff, Paulien G
Stellato, Rebecca K
van Baardwijk, Angela
de Vries, Kim
Ong, Francisca
Wiggenraad, Ruud
Bakri, Bonnie
Wester, Gerda
de Pree, Ilse
van Veelen, Lieneke
Budiharto, Tom
Schippers, Maaike
Reyners, Anna K L
de Graeff, Alexander |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2020 |
Reihe/Periodikum: |
van der Linden , Y M , Westhoff , P G , Stellato , R K , van Baardwijk , A , de Vries , K , Ong , F , Wiggenraad , R , Bakri , B , Wester , G , de Pree , I , van Veelen , L , Budiharto , T , Schippers , M , Reyners , A K L & de Graeff , A 2020 , ' Dexamethasone for the Prevention of a Pain Flare After Palliative Radiation Therapy for Painful Bone Metastases : The Multicenter Double-Blind Placebo-Controlled 3-Armed Randomized Dutch DEXA Study ' , International Journal of Radiation Oncology, Biology, Physics , vol. 108 , no. 3 , pp. 546-553 . https://doi.org/10.1016/j.ijrobp.2020.05.007 |
Schlagwörter: |
CANCER-PATIENTS
/ RADIOTHERAPY
/ PROPHYLAXIS
/ QUESTIONNAIRE |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-26671453 |
Datenquelle: |
BASE;
Originalkatalog |
Powered By: |
BASE |
Link(s) :
|
https://hdl.handle.net/11370/a0c35d88-acfa-499b-a6f1-a3af7f64fa4e |