Tofacitinib for ulcerative colitis:results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry

BACKGROUND: Tofacitinib is a Janus kinase inhibitor approved for the treatment of ulcerative colitis (UC). AIM: To evaluate effectiveness, safety and use of tofacitinib in daily practice. METHODS: UC patients initiating tofacitinib were prospectively enrolled in 15 hospitals in the Netherlands. Corticosteroid-free clinical remission (short clinical colitis activity index [SCCAI] ≤2), biochemical remission (faecal calprotectin level ≤250 µg/g), combined corticosteroid-free clinical and biochemical remission, predictors of remission, safety outcomes, treatment dose and effect on lipids were dete... Mehr ...

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Verfasser: Biemans, Vince B C
Sleutjes, Jasmijn A M
de Vries, Annemarie C
Bodelier, Alexander G L
Dijkstra, Gerard
Oldenburg, Bas
Löwenberg, Mark
van Bodegraven, Adriaan A
van der Meulen-de Jong, Andrea E
de Boer, Nanne K H
Srivastava, Nidhi
West, Rachel L
Römkens, Tessa E H
Horjus Talabur Horje, Carmen S
Jansen, Jeroen M
van der Woude, C Janneke
Hoekstra, Jildou
Weersma, Rinse K
van Schaik, Fiona D M
Hoentjen, Frank
Pierik, Marieke J
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Dutch Initiative on Crohn and Colitis , Biemans , V B C , Sleutjes , J A M , de Vries , A C , Bodelier , A G L , Dijkstra , G , Oldenburg , B , Löwenberg , M , van Bodegraven , A A , van der Meulen-de Jong , A E , de Boer , N K H , Srivastava , N , West , R L , Römkens , T E H , Horjus Talabur Horje , C S , Jansen , J M , van der Woude , C J , Hoekstra , J , Weersma , R K , van Schaik , F D M , Hoentjen , F & Pierik , M J 2020 , ' Tofacitinib for ulcerative colitis : results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry ' , Alimentary Pharmacology & Therapeutics , vol. 51 , no. 9 , pp. 880-888 . https://doi.org/10.1111/apt.15689
Schlagwörter: real world / tofacitinib / ulcerative colitis
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26671310
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/8d6c9804-d2d5-4451-825a-a9b1473819f9