BIO FOr CARE:biomarkers of hypertrophic cardiomyopathy development and progression in carriers of Dutch founder truncating MYBPC3 variants-design and status

Background Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic heart disease, commonly caused by truncating variants in the MYBPC3 gene. HCM is an important cause of sudden cardiac death; however, overall prognosis is good and penetrance in genotype-positive individuals is incomplete. The underlying mechanisms are poorly understood and risk stratification remains limited. Aim To create a nationwide cohort of carriers of truncating MYBPC3 variants for identification of predictive biomarkers for HCM development and progression. Methods In the multicentre, observational BIO FOr CARe... Mehr ...

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Verfasser: Jansen, M.
Christiaans, I.
van der Crabben, S. N.
Michels, M.
Huurman, R.
Hoedemaekers, Y. M.
Dooijes, D.
Jongbloed, J. D. H.
Boven, L. G.
Lekanne Deprez, R. H.
Wilde, A. A. M.
Jans, J. J. M.
van der Velden, J.
de Boer, R. A.
van Tintelen, J. P.
Asselbergs, F. W.
Baas, A. F.
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: Jansen , M , Christiaans , I , van der Crabben , S N , Michels , M , Huurman , R , Hoedemaekers , Y M , Dooijes , D , Jongbloed , J D H , Boven , L G , Lekanne Deprez , R H , Wilde , A A M , Jans , J J M , van der Velden , J , de Boer , R A , van Tintelen , J P , Asselbergs , F W & Baas , A F 2021 , ' BIO FOr CARE : biomarkers of hypertrophic cardiomyopathy development and progression in carriers of Dutch founder truncating MYBPC3 variants-design and status ' , Netherlands Heart Hournal , vol. 29 , pp. 318-329 . https://doi.org/10.1007/s12471-021-01539-w
Schlagwörter: Hypertrophic cardiomyopathy / MYBPC3 / Biomarkers / Prognosis
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26671080
Datenquelle: BASE; Originalkatalog
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Link(s) : https://hdl.handle.net/11370/704507f8-2916-4276-ac7c-6e8d69fd67b4