The development of eHealth is dramatically changing the way healthcare is provided and organized. eHealth applications are used not only by healthcare professionals but also by patients specifically to self-manage their health condition. The development of eHealth applications requires a new methodological approach, departing from the more conventional methods dedicated to designing health information systems. There is a gap between theories to design persuasive eHealth applications and practices. In the Netherlands, eHealth innovation emerges from three areas. In research, the development of eHealth application often remains in a pilot phase. Healthcare organizations are also keen to innovate but do not always have the know-how. We further witness technology push from business and industry, undermining the co-creation process of the innovation. We consequently advocate an integrated, systematic and practical but scientifically based methodology to design effective persuasive eHealth applications. This approach is being successfully embedded in our educational health informatics program.