Background and Purpose-The utility-weighted modified Rankin Scale (UW-mRS) has been proposed as a new patient-centered primary outcome in stroke trials. We aimed to describe utility weights for the mRS health states and to evaluate the statistical efficiency of the UW-mRS to detect treatment effects in stroke intervention trials. Methods-We used data of the 500 patients enrolled in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Utility values were elicited from the EuroQol Group 5-Dimension Self-Report Questionnaire... Mehr ...
| Verfasser: |
Dijkland, Simone A.
Voormolen, Daphne C.
Venema, Esmee
Roozenbeek, Bob
Polinder, Suzanne
Haagsma, Juanita A.
Nieboer, Daan
Chalos, Vicky
Yoo, Albert J.
Schreuders, Jennifer
van der Lugt, Aad
Majoie, Charles B. L. M.
Roos, Yvo B. W. E. M.
van Zwam, Wim H.
van Oostenbrugge, Robert J.
Steyerberg, Ewout W.
Dippel, Diederik W. J.
Lingsma, Hester F. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Dijkland , S A , Voormolen , D C , Venema , E , Roozenbeek , B , Polinder , S , Haagsma , J A , Nieboer , D , Chalos , V , Yoo , A J , Schreuders , J , van der Lugt , A , Majoie , C B L M , Roos , Y B W E M , van Zwam , W H , van Oostenbrugge , R J , Steyerberg , E W , Dippel , D W J , Lingsma , H F & MR CLEAN Investigators 2018 , ' Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials A Simulation Study ' , Stroke , vol. 49 , no. 4 , pp. 965-971 . https://doi.org/10.1161/STROKEAHA.117.020194 |
| Schlagwörter: |
brain ischemia
/ odds ratio
/ quality of life
/ self-report
/ stroke
/ QUALITY-OF-LIFE
/ TRAUMATIC BRAIN-INJURY
/ ACUTE ISCHEMIC-STROKE
/ INTRAARTERIAL TREATMENT
/ HEALTH STATES
/ DUTCH |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26664732 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/ed203bcd-a08a-4648-b6d8-68fc788082aa |
