Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors, performing genome-wide association studies for both asthma and COPD and combining the results in meta-analyses. Three loci showed potential involvement in both diseases: chr2p24.3, chr5q23.1 and chrl3q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) kappa beta pathway) and GNG5P5, respectively. Single nucleotide polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-w... Mehr ...
| Verfasser: |
Smolonska, J.
Koppelman, G.H.
Wijmenga, C.
Vonk, J.M.
Zanen, P.
Bruinenberg, M.
Curjuric, I.
Imboden, M.
Thun, G.A.
Franke, L.
Probst-Hensch, N.M.
Nürnberg, P.
Riemersma, R.A.
van Schayck, C.P.
Loth, D.W.
Brusselle, G.G.
Stricker, B.H.
Hofman, A.
Uitterlinden, A.G.
Lahousse, L.
London, S.J.
Loehr, L.R.
Manichaikul, A.
Barr, R.G.
Donohue, K.M.
Rich, S.S.
Pare, P.
Bossé, Y.
Hao, K.
van den Berge, M.
Groen, H.J.M.
Lammers, J.W.J.
Mali, W.
Boezen, H.M.
Postma, D.S. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2014 |
| Reihe/Periodikum: |
Smolonska , J , Koppelman , G H , Wijmenga , C , Vonk , J M , Zanen , P , Bruinenberg , M , Curjuric , I , Imboden , M , Thun , G A , Franke , L , Probst-Hensch , N M , Nürnberg , P , Riemersma , R A , van Schayck , C P , Loth , D W , Brusselle , G G , Stricker , B H , Hofman , A , Uitterlinden , A G , Lahousse , L , London , S J , Loehr , L R , Manichaikul , A , Barr , R G , Donohue , K M , Rich , S S , Pare , P , Bossé , Y , Hao , K , van den Berge , M , Groen , H J M , Lammers , J W J , Mali , W , Boezen , H M & Postma , D S 2014 , ' Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis ' , European Respiratory Journal , vol. 44 , no. 4 , pp. 860-872 . https://doi.org/10.1183/09031936.00001914 |
| Schlagwörter: |
OBSTRUCTIVE PULMONARY-DISEASE
/ LUNG-FUNCTION DECLINE
/ SPIROMETRIC PHENOTYPES
/ SUSCEPTIBILITY GENE
/ LINKAGE ANALYSIS
/ CANDIDATE GENE
/ ADAM33 GENE
/ FOLLOW-UP
/ ASSOCIATION
/ HYPERRESPONSIVENESS |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-26664564 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/bf5c7aa9-9837-4c53-b93e-0b3430220ef2 |
