Founder mutations among the Dutch

Founder mutations among the Dutch. Zeegers MP, van Poppel F, Vlietinck R, Spruijt L, Ostrer H. Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands. Many genetic disorders demonstrate mutations that can be traced to a founder, sometimes a person who can be identified. These founder mutations have generated considerable interest, because they facilitate studies of prevalence and penetrance and can be used to quantify the degree of homogeneity within a population. This paper reports on founder mutations among the Dutch and relates their occurrence t... Mehr ...