Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch va... Mehr ...

Verfasser: Borgers, J. S.W.
Burgers, F. H.
Schina, A.
Van Not, O. J.
van den Eertwegh, A. J.M.
Blank, C. U.
Aarts, M. J.B.
van den Berkmortel, F. W.P.J.
de Groot, J. W.B.
Hospers, G. A.P.
Kapiteijn, E.
Piersma, D.
van Rijn, R. S.
Boer, A. M.Stevense den
van der Veldt, A. A.M.
Vreugdenhil, G.
Boers-Sonderen, M. J.
Wouters, M. W.J.M.
Suijkerbuijk, K. P.M.
van Thienen, J. V.
Haanen, J. B.A.G.
Dokumenttyp: Artikel
Erscheinungsdatum: 2024
Reihe/Periodikum: Borgers , J S W , Burgers , F H , Schina , A , Van Not , O J , van den Eertwegh , A J M , Blank , C U , Aarts , M J B , van den Berkmortel , F W P J , de Groot , J W B , Hospers , G A P , Kapiteijn , E , Piersma , D , van Rijn , R S , Boer , A M S D , van der Veldt , A A M , Vreugdenhil , G , Boers-Sonderen , M J , Wouters , M W J M , Suijkerbuijk , K P M , van Thienen , J V & Haanen , J B A G 2024 , ' Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort ' , Pigment Cell & Melanoma Research , vol. 37 , no. 1 , pp. 15-20 . https://doi.org/10.1111/pcmr.13117
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-26664077
Datenquelle: BASE; Originalkatalog
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Link(s) : https://cris.maastrichtuniversity.nl/en/publications/4b238e2f-d6d6-444b-98aa-f9d534ad9895