Association of P2X(7) receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

The P2X(7) receptor is thought to be involved in bone physiology in a pro-osteogenic manner. Therefore, we examined associations between genetic variations in the P2X(7) receptor gene and bone mineral density (BMD). We found an association between four non-synonymous polymorphism of the human P2X(7) receptor and the risk of osteoporosis. The purpose of this study was to determine whether genetic variation in the P2X(7) receptor gene (P2RX7) is associated with decreased BMD and risk of osteoporosis in fracture patients. Six hundred ninety women and 231 men aged a parts per thousand yen50 years... Mehr ...