HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.
Recently, the hematopoietically expressed homeobox (HHEX) gene, encoding a transcription factor, was identified in a large genome-wide scan in French individuals as a type 2 diabetes (T2D)-susceptibility locus. We aimed to check whether this finding could be replicated in a Dutch T2D cohort. Two common variants (rs7923837 and rs1111875) located near the HHEX gene were genotyped in 501 unrelated T2D patients and in 920 healthy controls. The major alleles of both variants were overrepresented in T2D cases compared with controls (66.7 vs 64.1%, P=0.16 for rs7923837 and 64.6 vs 60.4%, P=0.027 for... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2008 |
| Reihe/Periodikum: | van Vliet-Ostaptchouk , J V , Onland-Moret , N C , van Haeften , T W , Franke , L , Elbers , C C , Shiri-Sverdlov , R , van der Schouw , Y T , Hofker , M H & Wijmenga , C 2008 , ' HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. ' , European Journal of Human Genetics , vol. 16 , no. 5 , pp. 652-656 . https://doi.org/10.1038/sj.ejhg.5202008 |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26663851 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://cris.maastrichtuniversity.nl/en/publications/0d4883fd-3baa-4e57-b7bf-3a90af20c2d5 |
