Coronary heart disease mortality in treated familial hypercholesterolaemia: Update of the UK Simon Broome FH register
BACKGROUND AND AIMS: Patients with familial hypercholesterolaemia (FH) have an elevated risk of coronary heart disease (CHD). Here we compare changes in CHD mortality in patients with heterozygous (FH) pre 1992, before lipid-lowering therapy with statins was used routinely, and in the periods 1992–2008 and 2008–2016. METHODS: 1903 Definite (DFH) and 1650 Possible (PFH) patients (51% women) aged 20–79 years, recruited from 21 lipid clinics in the United Kingdom and followed prospectively between 1980 and 2016 for 67,060 person-years. The CHD standardised mortality ratio (SMR) compared to the po... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Verlag/Hrsg.: |
ELSEVIER IRELAND LTD
|
Schlagwörter: | Heterozygous familial hypercholesterolemia / Coronary mortality / Cancer mortality / Dutch lipid clinic network score |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26663548 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://discovery.ucl.ac.uk/id/eprint/10054723/1/Humphries_Coronary%20heart%20disease%20mortality%20in%20treated%20familial%20hypercholesterolaemia.%20Update%20of%20the%20UK%20Simon%20Broome%20FH%20register_VoR.pdf |