Association mapping and fine-mapping of the major clinical mastitis resistance QTL on BTA6.
(A) Association mapping performed with imputed BovineHD variants on BTA6. The association signal near BTA 6:88.6 Mb, shown in other dairy cattle populations was replicated in the current Dutch HF population. (B) Fine-mapping performed with imputed WGS variants in BTA 6:84–93 Mb region. A strong association signal was shown in a 200-Kb region (BTA 6:88.5–88.7 Mb), spanning over GC gene. Our lead SNP (rs110813063, marked with green and vertical dotted line) has not been reported as a candidate SNP in other CM fine-mapping studies. CM candidate SNPs from other fine-mapping studies are marked as y... Mehr ...
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| Dokumenttyp: | Image |
| Erscheinungsdatum: | 2021 |
| Schlagwörter: | Genetics / Neuroscience / Evolutionary Biology / Cancer / Infectious Diseases / Plant Biology / Virology / Environmental Sciences not elsewhere classified / Biological Sciences not elsewhere classified / dairy cattle Clinical mastitis / multiplicated allele / SNP / vitamin D pathway / vitamin D binding protein / group-specific component gene / Dutch dairy cattle population / CM resistance QTL / GC gene enhancer / CNV / dairy cattle breeds / variant / 12 kb multi-allelic copy number var. / expression QTL mapping |
| Sprache: | unknown |
| Permalink: | https://search.fid-benelux.de/Record/base-26662330 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://doi.org/10.1371/journal.pgen.1009331.g001 |
(A) Association mapping performed with imputed BovineHD variants on BTA6. The association signal near BTA 6:88.6 Mb, shown in other dairy cattle populations was replicated in the current Dutch HF population. (B) Fine-mapping performed with imputed WGS variants in BTA 6:84–93 Mb region. A strong association signal was shown in a 200-Kb region (BTA 6:88.5–88.7 Mb), spanning over GC gene. Our lead SNP (rs110813063, marked with green and vertical dotted line) has not been reported as a candidate SNP in other CM fine-mapping studies. CM candidate SNPs from other fine-mapping studies are marked as yellow. (C) Conditional analyses including GC CNV as a covariate nullify the association signal.