USF1 Contributes to High Serum Lipid Levels in Dutch FCHL Families and U.S. Whites With Coronary Artery Disease
Objective— Familial combined hyperlipidemia (FCHL) characterized by high serum total cholesterol and/or triglycerides (TGs) is a common dyslipidemia predisposing to coronary artery disease (CAD). Recently, the upstream transcription factor 1 ( USF1 ) was linked and associated with FCHL and TGs in Finnish FCHL families. Here we examined the previously associated rs3737787 SNP in extended Dutch FCHL families (n=532) and in a cohort of US subjects who underwent diagnostic coronary angiography (n=1533). Methods and Results— In males of the Dutch FCHL families, we observed significant sex-dependent... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2007 |
Reihe/Periodikum: | Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 27, issue 10, page 2222-2227 ; ISSN 1079-5642 1524-4636 |
Verlag/Hrsg.: |
Ovid Technologies (Wolters Kluwer Health)
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Schlagwörter: | Cardiology and Cardiovascular Medicine |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26657473 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1161/atvbaha.107.151530 |