Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma
Background Familial clustering of melanoma suggests a shared genetic predisposition among family members, but only 10%–40% of familial cases carry a pathogenic variant in a known high-risk melanoma susceptibility gene. We investigated whether a melanoma-specific Polygenic Risk Score (PRS) is associated with melanoma risk in patients with genetically unexplained familial melanoma. Methods Dutch familial melanoma cases (n=418) were genotyped for 46 SNPs previously identified as independently associated with melanoma risk. The 46-SNP PRS was calculated and standardised to 3423 healthy controls (s... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2020 |
Reihe/Periodikum: | Journal of Medical Genetics ; volume 58, issue 11, page 760-766 ; ISSN 0022-2593 1468-6244 |
Verlag/Hrsg.: |
BMJ
|
Schlagwörter: | Genetics (clinical) / Genetics |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26651910 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://dx.doi.org/10.1136/jmedgenet-2020-107251 |