Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases. OBJECTIVE: We sought to determine, in terms of their sputum cellular and mediator profiles, the extent to which they represent distinct or overlapping conditions supporting either the "British" or "Dutch" hypotheses of airway disease pathogenesis. METHODS: We compared the clinical and physiological characteristics and sputum mediators between 86 subjects with severe asthma and 75 with moderate-to-severe COPD. Biological subgroups were determined using factor and cluster analyses on 18 sputum cytokin... Mehr ...
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Dokumenttyp: | Journal article |
Erscheinungsdatum: | 2015 |
Verlag/Hrsg.: |
Elsevier
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Schlagwörter: | Asthma and COPD overlap / cytokines / factor and cluster analyses / Aged / Asthma / Cluster Analysis / Female / Forced Expiratory Volume / Great Britain / Humans / Leukocyte Count / Male / Middle Aged / Pulmonary Disease / Chronic Obstructive / Sputum |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26635843 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://www.sciencedirect.com/science/article/pii/S0091674914009518 |