Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma
Background: Familial clustering of melanoma suggests a shared genetic predisposition among family members, but only 10%–40% of familial cases carry a pathogenic variant in a known high-risk melanoma susceptibility gene. We investigated whether a melanoma-specific Polygenic Risk Score (PRS) is associated with melanoma risk in patients with genetically unexplained familial melanoma. Methods: Dutch familial melanoma cases (n=418) were genotyped for 46 SNPs previously identified as independently associated with melanoma risk. The 46-SNP PRS was calculated and standardised to 3423 healthy controls... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2021 |
Verlag/Hrsg.: |
BMJ
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Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26635828 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://eprints.whiterose.ac.uk/166730/ |