Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population
Background Despite extensive research on the genetic determinants of glaucoma, the genes identified to date explain only a small proportion of cases in the general population. Methods Genome-wide linkage and association analyses of quantitative traits related to glaucoma were performed: intraocular pressure, size and morphology of the optic disc (individual and combined by method of principal components) and thickness of the retinal nerve fibre layer (RNFL), in a large pedigree from a genetically isolated Dutch population. Results For the size of the optic disc, the study demonstrated a signif... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 2011 |
Verlag/Hrsg.: |
British Medical Journal Publishing Group
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Schlagwörter: | Genome-wide studies |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26632976 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://jmg.bmj.com/cgi/content/short/jmedgenet-2011-100436v1 |