No association of estrogen receptor {alpha} and cytochrome P450c17{alpha} polymorphisms with age at menopause in a Dutch cohort
BACKGROUND: Age at menopause is under strong genetic control. So far, genetic variations of only one gene, the Pvu II polymorphism of the estrogen receptor α (ERα) gene, have been shown to be associated with age at onset of menopause. This study aims to investigate whether Pvu II, Xba I and B-variant polymorphisms of the ERα gene, and the Msp AI polymorphism of the cytochrome P450c17α (CYP17) gene are associated with age at menopause in a Dutch cohort. METHODS: DNA was isolated from urine samples of 385 Caucasian women with natural menopause and the genotypes of the four polymorphisms were det... Mehr ...
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Dokumenttyp: | TEXT |
Erscheinungsdatum: | 2005 |
Verlag/Hrsg.: |
Oxford University Press
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Schlagwörter: | Puberty/aging and HRT |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26632737 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://humrep.oxfordjournals.org/cgi/content/short/20/2/536 |