Associations With Tight Junction Genes Pard3 And Magi2 In Dutch Patients Point To A Common Barrier Defect For Celiac Disease And Ulcerative Colitis

Background: Celiac disease (GSE) and inflammatory bowel disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal permeability, initiated by gluten exposure (GSE) or bacterial interactions (IBD). Previous studies showed association of both diseases with variants in MYO9B , presumably involved in epithelial permeability. Aim: We hypothesized that genetic variants in tight junction genes might affect epithelial barrier function, thus contributing to a shared pathogenesis of GSE and IBD. Methods: We tested this hypothesis with a comprehensive genetic association analys... Mehr ...