Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP). Post-mortem frontal and occipital cortical brain tissue from nine patients and nine age-related controls was used for RNA sequencing to identify biological pathways affected in HCHWA-D. Although previous studies indicated that pathology is more severe in the occipital lobe in HCHWA-D compared to the frontal lobe, the current study... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2018 |
Reihe/Periodikum: | Frontiers in Aging Neuroscience, Vol 10 (2018) |
Verlag/Hrsg.: |
Frontiers Media S.A.
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Schlagwörter: | RNA sequencing and transcriptome analysis / hereditary cerebral hemorrhage with amyloidosis-Dutch type / familial cerebral amyloid angiopathy / E22Q amyloid β / E693Q mutation / extracellular matrix remodeling / Neurosciences. Biological psychiatry. Neuropsychiatry / RC321-571 |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-26629490 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://doi.org/10.3389/fnagi.2018.00102 |