Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease
BackgroundWe previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated whether FXR activation is repressed in the ileum and colon of inflammatory bowel disease (IBD) patients in remission. Additionally, we evaluated whether genetic variation in FXR is associated with IBD.MethodsmRNA expression of FXR and FXR target gene SHP was determined in ileal and colonic biopsies of patients with Crohn's colitis (n = 15) and ulcerati... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2011 |
Reihe/Periodikum: | PLOS ONE, vol 6, iss 8 |
Verlag/Hrsg.: |
eScholarship
University of California |
Schlagwörter: | Clinical Research / Digestive Diseases / Autoimmune Disease / Genetics / Crohn's Disease / Inflammatory Bowel Disease / 2.1 Biological and endogenous factors / Aetiology / Oral and gastrointestinal / Case-Control Studies / Colitis / Ulcerative / Colon / Female / Gene Expression / Genetic Variation / Humans / Ileum / Inflammatory Bowel Diseases / Male / Polymorphism / Single Nucleotide / RNA / Messenger / Receptors / Cytoplasmic and Nuclear / Dutch Initiative on Crohn / General Science & Technology |
Sprache: | unknown |
Permalink: | https://search.fid-benelux.de/Record/base-26619517 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://escholarship.org/uc/item/50b1d5jc |