Brief report:Normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curacao (The Netherlands Antilles)
This study investigated the relationship between platelet (PLT) serotonin (5-HT) and intestinal permeability in children with pervasive developmental disorders (PDD). Differential sugar absorption and PLT 5-HT were determined in 23 children with PDD. PLT 5-HT (2.0-7.1 nmol/10(9) PLT) was elevated in 4/23 patients. None exhibited elevated intestinal permeability (lactulose/mannitol ratio: 0.008-0.035 mol/mol). PLT 5-HT did not correlate with intestinal permeability or GI tract complaints. PLT 5-HT correlated with 24 h urinary 5-hydroxyindoleacetic acid (5-HIAA; p = .034). Also urinary 5-HIAA an... Mehr ...
| Verfasser: | |
|---|---|
| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2008 |
| Reihe/Periodikum: | Kemperman , R F J , Boutier , A I , Muskiet , F D , Kema , I P & Muskiet , F A J 2008 , ' Brief report : Normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curacao (The Netherlands Antilles) ' , Journal of Autism and Developmental Disorders , vol. 38 , no. 2 , pp. 401-406 . https://doi.org/10.1007/s10803-007-0399-8 |
| Schlagwörter: | child development disorders / pervasive / platelets / serotonin / gastrointestinal / permeability / IRRITABLE-BOWEL-SYNDROME / CARCINOID-TUMORS / AUTISM / PLASMA / PREDOMINANT / SUGARS / HPLC |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-26617230 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://hdl.handle.net/11370/f86124f2-3b3a-476d-9831-3c91e7cc46c3 |
This study investigated the relationship between platelet (PLT) serotonin (5-HT) and intestinal permeability in children with pervasive developmental disorders (PDD). Differential sugar absorption and PLT 5-HT were determined in 23 children with PDD. PLT 5-HT (2.0-7.1 nmol/10(9) PLT) was elevated in 4/23 patients. None exhibited elevated intestinal permeability (lactulose/mannitol ratio: 0.008-0.035 mol/mol). PLT 5-HT did not correlate with intestinal permeability or GI tract complaints. PLT 5-HT correlated with 24 h urinary 5-hydroxyindoleacetic acid (5-HIAA; p = .034). Also urinary 5-HIAA and urinary 5-HT were interrelated (p = .005). A link between hyperserotonemia and increased intestinal permeability remained unsupported. Increased PLT 5-HT in PDD is likely to derive from increased PLT exposure to 5-HT. Longitudinal studies, showing the (in) consistency of abnormal intestinal permeability and PLT 5-HT, may resolve present discrepancies in the literature.