The research leading to these results was funded by the Spanish Ministry of Health (FIS-PI11/00610, FIS-PI041436, FIS-PI081151, FIS-PI042018, and FIS-PI09/02311), the European Union (EU) (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), the Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/01007, 11/02591, CP11/00178, FIS-PI06/0867, and FIS-PS09/00090), the Conselleria de Sanitat Generalitat Valenciana, the Generalitat de Catalunya-CIRIT (1999SGR 00241), the Obre Social Cajastur, the Universidad de Oviedo, the Department of Health of the Basque Government (2005111093 and 2009111069), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001). The ENVIRONAGE cohort is supported by the EU Program “Ideas” (ERC-2012-StG 310898) and by the Flemish Fund for Scientific Research (FWO 1516112N and G073315N). ; Clemente, D.B.P., Casas, M., Vilahur, N., Begiristain, H., Bustamante, M., Carsin, A., Fernández, M.F., Fierens, F., Gyselaers, W., Iñiguez, C., Janssen, B.G., Lefebvre, W., Llop, S., Olea, N., Pedersen, M., Pieters, N., Marina, L.S., Souto, A., Tardón, A., Vanpoucke, C., Vrijheid, M., Sunyer, J., Nawrot, T.S.