Continued high prevalence of G2P[4] rotavirus strains in Belgium : vaccine induced selective pressure?

Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica) ; Group A rotaviruses are the leading cause of severe diarrhoea in children under 5 years of age worldwide, accounting for approximately 600,000 child deaths each year. Two rotavirus vaccines, Rotarix® and RotaTeq®, have been licensed in Belgium, and they have strongly reduced the disease caused by rotavirus infections. However, the rotavirus seasons following Rotarix® introduction in 2006 were marked by a relative increase of G2P[4] rotavirus strain prevalence, when compared with seasons b... Mehr ...